fpocket is a very fast open source protein pocket (cavity) detection algorithm based on Voronoi tessellation. It was developed in the C programming language and is currently only available as command line driven program. A GUI is in development and mdpocket (fpocket on md trajectories) is on the way. fpocket includes two other programs (dpocket & tpocket) that allow you to extract pocket descriptors and test own scoring functions respectively.
As the algorithm is very fast it can be used on a large scale level (PDB size for instance). If you use fpocket for publication, please cite : Vincent Le Guilloux, Peter Schmidtke and Pierre Tuffery, "Fpocket: An open source platform for ligand pocket detection", BMC Bioinformatics, 2009, 10:168

Vincent and me are currently working on the first official release of mdpocket. Mdpocket allows pocket tracking on molecular dynamics trajectories. For knowing when the official release will be scheduled, please subscribe to the fpocket newsletter.

New tutorials and an up to date manual will also be available then.

The fpocket development team announces that within a short time a very nice and nifty graphical user interface (JAVA based) will be available within the official release. Until this release you still have to wait a little bit, but feel free to subscribe to the fpocket newsletter in order to stay tuned about new releases.

Furthermore a first draft of a fpocket reference programmers guide is available on this website.

The developers of fpocket are proud to announce that our fposter (the scientific poster explaining fpocket) won the best poster price at the "Journées Nationales de Chémoinformatique" in Montpellier. This meeting was the annual assembly of the growing SFCI (Société Francaise de Chémoinformatique) which reunited the French chemoinformatics community.

We would like to thank all participants and people who voted for fpocket. You can download the fposter here.

The fpaper (paper explaining the fpocket method) submitted to BMC Bioinformatics has been accepted for publication and was published the same day. Take a look at the paper if you want some details about how fpocket does what it is doing best...detecting protein ligand binding pockets : BMC Bioinformatics paper

In order to cite fpocket please use the following references :

Vincent Le Guilloux, Peter Schmidtke and Pierre Tuffery,
"Fpocket: An open source platform for ligand pocket detection", BMC Bioinformatics, 2009, 10:168